EGFR T790M/VEGFR-2-IN-1

EGFR T790M/VEGFR-2-IN-1 (Compound 6) is a dual EGFR T790M mutant (IC50=0.26 μM) and VEGFR-2 (IC50=0.95 μM) inhibitor. EGFR T790M/VEGFR-2-IN-1 blocks tumor cell proliferation and angiogenesis signaling pathways. EGFR T790M/VEGFR-2-IN-1 exhibits potent cytotoxicity against multiple cancer cell lines (HCT116, MCF-7, HepG2, A549; IC50=5.35-9.90 μM) . EGFR T790M/VEGFR-2-IN-1 is promising for research of non-small cell lung cancer and solid tumors[1].

Product Specifications

UNSPSC

12352005

Target

EGFR; VEGFR

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

O=S(C1=CC=C(/N=N/C2=C3N=C(N)C(C#N)=C(C4=CC=CO4)N3N=C2N)C=C1)(/N=C(N)\N)=O

Molecular Formula

C18H15N11O3S

Molecular Weight

465.45

References & Citations

[1]Alsulaimany M, et al. ADMET, docking, anticancer evaluations, design and synthesis of pyrazolo[1,5-a]pyrimidines substituted with furan and phenyldiazene as dual EGFRT790M and VEGFR-2 inhibitors. Bioorg Chem. 2025 Aug;163:108746.