SMU-C68
SMU-C68 is a highly selective small-molecule TLR1/2 heterodimer agonist (EC50=0.009 μM) . SMU-C68 activates NF-κB and MAPK pathways to promote pro-inflammatory cytokine release (e.g., TNF-α, IL-1β) . SMU-C68 is promising for research of cancers[1].
Product Specifications
CAS Number
2677039-75-5
UNSPSC
12352005
Target
NF-κB; p38 MAPK; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Field of Research
Cancer
Smiles
CC(OC(C1=C(SC2=C1CCC2)NC(NC3=C4C=CC=NC4=CC=C3)=S)=O)C
Molecular Formula
C21H21N3O2S2
Molecular Weight
411.54
References & Citations
[1]Zeng X, et al. Discovery of potent, selective human TLR1/2 agonists: N-quinoline-N'- (thiophen-2-yl) thiourea analogs for potential cancer immunotherapy. Eur J Med Chem. 2025 Nov 5;297:117968.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR1; TLR2
Frequently Asked Questions
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