SMU-C68

SMU-C68 is a highly selective small-molecule TLR1/2 heterodimer agonist (EC50=0.009 μM) . SMU-C68 activates NF-κB and MAPK pathways to promote pro-inflammatory cytokine release (e.g., TNF-α, IL-1β) . SMU-C68 is promising for research of cancers[1].

Product Specifications

CAS Number

[2677039-75-5]

UNSPSC

12352005

Target

NF-κB; p38 MAPK; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Field of Research

Cancer

Smiles

CC(OC(C1=C(SC2=C1CCC2)NC(NC3=C4C=CC=NC4=CC=C3)=S)=O)C

Molecular Formula

C21H21N3O2S2

Molecular Weight

411.54

References & Citations

[1]Zeng X, et al. Discovery of potent, selective human TLR1/2 agonists: N-quinoline-N'- (thiophen-2-yl) thiourea analogs for potential cancer immunotherapy. Eur J Med Chem. 2025 Nov 5;297:117968.