EGFR WT/T790M-IN-3
EGFR WT/T790M-IN-3 is an irreversible covalent EGFRWT and EGFRT790M inhibitor with IC50s value of 28.1 and 24.6 nM. EGFR WT/T790M-IN-3 hampers tubulin polymerization through IC50 value of 5.1 μM. EGFR WT/T790M-IN-3 shows significant anti-proliferative effects on HCT116 and T47D cells, with IC50 values of 3.12 and 4.12 μM, respectively. EGFR WT/T790M-IN-3 can be used for the study of cancers such as non-small cell lung cancer, colon cancer and breast cancer[1].
Product Specifications
UNSPSC
12352100
Target
EGFR; Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
[H]C1=CC=C(C=C1)/C(C)=N\NC(C2=C(C3=C(SC(C(N/N=C(C4=CC=C(C=C4)[H])/C)=O)=C3N)S2)N)=O
Molecular Formula
C24H22N6O2S2
Molecular Weight
490.60
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
TNF alpha (J2D10), CF594 conjugate, 0.1mg/mL
