EGFR WT/T790M-IN-3

EGFR WT/T790M-IN-3 is an irreversible covalent EGFRWT and EGFRT790M inhibitor with IC50s value of 28.1 and 24.6 nM. EGFR WT/T790M-IN-3 hampers tubulin polymerization through IC50 value of 5.1 μM. EGFR WT/T790M-IN-3 shows significant anti-proliferative effects on HCT116 and T47D cells, with IC50 values of 3.12 and 4.12 μM, respectively. EGFR WT/T790M-IN-3 can be used for the study of cancers such as non-small cell lung cancer, colon cancer and breast cancer[1].

Product Specifications

UNSPSC

12352100

Target

EGFR; Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

[H]C1=CC=C(C=C1)/C(C)=N\NC(C2=C(C3=C(SC(C(N/N=C(C4=CC=C(C=C4)[H])/C)=O)=C3N)S2)N)=O

Molecular Formula

C24H22N6O2S2

Molecular Weight

490.60

References & Citations

[1]Aboelez MO, et al. Novel 3,4-diaminothieno[2,3-b]thiophene-2,5-dicarbohydrazide-based scaffolds as EGFRWT, EGFRT790M, and tubulin polymerization inhibitors with anti-proliferative activity. Bioorg Chem. 2025 Aug;163:108728.