Arf1-GEFs-IN-1

Arf1-GEFs-IN-1 is a potent and orally active ADP-ribosylation factor 1- guanine nucleotide exchange factors (Arf1-GEFs) inhibitor with an IC50 value of 40.85 μM against CT26 cells. Arf1-GEFs-IN-1 primarily mediates tumor regression by triggering anti-tumor immune responses, rather than through direct cytotoxicity. Arf1-GEFs-IN-1 effectively promotes CCL5 expression, demonstrates excellent in vivo efficacy. Arf1-GEFs-IN-1 can be used for the study of colon cancer[1].

Product Specifications

CAS Number

[3091068-95-7]

UNSPSC

12352005

Target

Arf Family GTPase

Related Pathways

GPCR/G Protein

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CN1CCC2=C(SC3=NC=NC(N/N=C/C4=CC5=C(NC=C5)C=C4)=C32)C1

Molecular Formula

C19H18N6S

Molecular Weight

362.45

References & Citations

[1]Li N, et al. Design, synthesis and biological evaluation of (E) -4- (2- ((1H-indol-5-yl) methylene) hydrazineyl) -5,6,7,8-tetrahydropyrido [4',3':4,5] thieno[2,3-d] pyrimidine derivatives as Arf1-GEFs inhibitors for the treatment of colon cancer. Eur J Med Chem. 2025 Nov 5;297:117962.