αMβ2 integrin agonist-1
αMβ2 integrin agonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory activity (EC50=1.4 nM) . αMβ2 integrin agonist-1 activates integrin-mediated cell adhesion and JNK/ERK signaling. αMβ2 integrin agonist-1 induces tumor-associated macrophage repolarization and enhances antitumor T-cell immune responses. αMβ2 integrin agonist-1 is promising for research of cancers and chronic inflammatory diseases (e.g., pancreatic cancer, rheumatoid arthritis) [1].
Product Specifications
UNSPSC
12352005
Target
ERK; Integrin; JNK
Related Pathways
Cytoskeleton; MAPK/ERK Pathway; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Smiles
[NH3+]C1=CC=C(C=C1)CNC(N[C@H](C(O)=O)CC(O)=O)=O.O=C([O-])C(F)(F)F
Molecular Formula
C14H16F3N3O7
Molecular Weight
395.29
References & Citations
[1]Giraldi V, et al. Targeting α4β1 integrin: from cyclic to linear ligands, effects of chemical modifications. Eur J Med Chem. 2025 Nov 5;297:117965.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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