α5β1 integrin agonist-2
α5β1 integrin agonist-2 (Compound 2) is a highly selective α5β1 integrin agonist (EC50=45.98 nM) . α5β1 integrin agonist-2 enhances extracellular matrix adhesion and Akt/ERK signaling activation. α5β1 integrin agonist-2 is promising for research of ischemic stroke[1].
Product Specifications
UNSPSC
12352005
Target
Akt; ERK; Integrin
Related Pathways
Cytoskeleton; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.80
Smiles
O=C(O)CC(C1)N(C(NC2=CC(F)=CC=C2C)=O)C1=O
Molecular Formula
C13H13FN2O4
Molecular Weight
280.25
References & Citations
[1]Giraldi V, et al. Targeting α4β1 integrin: from cyclic to linear ligands, effects of chemical modifications. Eur J Med Chem. 2025 Nov 5;297:117965.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
α5β1
Available Sizes
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