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5-HT2AR-IN-1

5-HT2AR-IN-1 (Compound Ie) is an orally active 5-hydroxytryptamine 2A receptor (5-HT2AR) inhibitor with antidepressant efficacy. 5-HT2AR-IN-1 reduces 5-HT2AR expression and SERT protein levels. 5-HT2AR-IN-1 is promising for research of central nervous system (CNS), such as depression and addiction-related disorders[1].

Product Specifications

CAS Number

780703-57-3

UNSPSC

12352005

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

COC1=CC2=C(CC3NCCC4=CC(OC)=C(C2=C43)OC)C=C1

Molecular Formula

C19H21NO3

Molecular Weight

311.37

References & Citations

[1]Wan Y, et al. Methylenedioxy open-loop and closed-loop aporphines designed for the evaluation of potential antidepressants. Eur J Med Chem. 2025 Nov 5;297:117969.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor

Frequently Asked Questions

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