ABT-002
ABT-002 is a molecular glue degrader targeting GSPT1 and NEK7. ABT-002 is the active metabolite of ABS-752. ABT-002 is promising for research of hepatocellular carcinoma (HCC).
Product Specifications
CAS Number
2438239-83-7
UNSPSC
12352005
Target
Molecular Glues; NEKs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=C(C(C(O)=O)=C3)F
Molecular Formula
C14H11FN2O5
Molecular Weight
306.25
References & Citations
[1]Glaza P, et al. Targeted degradation of GSPT1 and NEK7 by a molecular glue prodrug for treatment of HCC[J]. bioRxiv, 2025: 2025.06. 25.661504.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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