SJ11646
SJ11646 is a Dasatinib -based LCK PROTAC degrader with a DC50 of 0.00838 pM. SJ11646 has potent cytotoxicity against LCK-activated T-cell acute lymphoblastic leukemia (T-ALL) cells and primary leukemia samples with drastically prolonged suppression of LCK signaling, and induces T-ALL apoptosis. SJ11646 binds to 51 human kinases with a high affinity (particularly ABL1, KIT, and DDR1). SJ11646 has superior antileukemic efficacy in T-ALL mice model.[2]. Pink: LCK ligand (HY-107447) ; Blue: CRBN ligase ligand (HY-163169) ; Black: linker (HY-76667)
Product Specifications
CAS Number
2933135-82-9
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl; Discoidin Domain Receptor; PROTACs; Src
Related Pathways
Apoptosis; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCCNC(COC4=CC=C(C(CC5)C(NC5=O)=O)C=C4)=O)CC3)=C2)S1)NC6=C(C)C=CC=C6Cl
Molecular Formula
C36H40ClN9O5S
Molecular Weight
746.28
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Abl; DDR1; Lck
Frequently Asked Questions
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