Lck degrader-1

Lck degrader-1 (Compound 17) is a molecular glue degrader targeting lymphocyte-specific protein tyrosine kinase (LCK) (DC50=23.1 nM) . Lck degrader-1 is promising for research of T-cell acute lymphoblastic leukemia (T-ALL) [1].

Product Specifications

CAS Number

[3095033-62-5]

UNSPSC

12352005

Target

Molecular Glues; Src

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CCC1=C(NC2=C1C=CC=C2CN)C(NC3=CC4=C(C(N(C5CCC(NC5=O)=O)C4)=O)C=C3)=O

Molecular Formula

C25H25N5O4

Molecular Weight

459.50

References & Citations

[1]Yoshimura S, et al. LCK-targeting molecular glues overcome resistance to inhibitor-based therapy in T-cell acute lymphoblastic leukemia[J]. bioRxiv, 2025: 2025.07. 03.663042.