PIM1-IN-8
PIM1-IN-8 is a PIM1/p65 pathway inhibitor. PIM1-IN-8 suppresses the expression of α-SMA and collagen I in activated fibroblasts and blocks TGF-β induced migration. PIM1-IN-8 alleviates pulmonary fibrosis in a Bleomycin (BLM) (HY-17565A) -induced pulmonary fibrosis mice model. PIM1-IN-8 can be used for the study of idiopathic pulmonary fibrosis (IPF) [1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; NF-κB; Pim
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; NF-κB
Field of Research
Inflammation/Immunology
Smiles
O=C(NC1=CC(C(C)=O)=C(O)C=C1OC)C2=CC=CC(C)=C2
Molecular Formula
C17H17NO4
Molecular Weight
299.32
References & Citations
[1]Zhang F, et al. Novel paeonol derivatives: Design, synthesis, and their activity in relieving idiopathic pulmonary fibrosis via the PIM1/p65 pathway. Bioorg Chem. 2025 Aug;163:108731.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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