10-Butyl Ether Minocycline
10-Butyl Ether Minocycline (BEM), a Minocycline (HY-17412A) derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 µM and 47.0 µM, respectively. 10-Butyl Ether Minocycline suppresses LPS (HY-D1056) -induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine (HY-N0390) -induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder (AUD) [1].
Product Specifications
CAS Number
[488815-65-2]
Product Name Alternative
BEM
UNSPSC
12352005
Target
Lipoxygenase; MMP; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Neurological Disease; Inflammation/Immunology
Smiles
[H][C@@]12C[C@@]3(CC4=C(C=CC(OCCCC)=C4C(C3=C([C@@]1(C(C(C(N)=O)=C([C@H]2N(C)C)O)=O)O)O)=O)N(C)C)[H]
Molecular Formula
C27H35N3O7
Molecular Weight
513.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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