MGB1Y
MGB1Y is a noncovalent DNA minor groove binder (MGB) . MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia[1].
Product Specifications
UNSPSC
12352005
Target
DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Topoisomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C(C1=C(C(C)C)SC(NC(C2=CC(NC(C3=CC=C(C#CC4=CSC=N4)C=C3)=O)=CN2C)=O)=N1)NCCCN(C)C
Molecular Formula
C30H33N7O3S2
Molecular Weight
603.76
References & Citations
[1]Msallam YA, et al. Design, Synthesis, and Anticancer Evaluation of Novel MGBs with Alkyne-Linked Thiazole Moieties. J Med Chem. 2025 Jul 24;68 (14) :15065-15084.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
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