MGB1Y

MGB1Y is a noncovalent DNA minor groove binder (MGB) . MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia[1].

Product Specifications

UNSPSC

12352005

Target

DNA Alkylator/Crosslinker; DNA/RNA Synthesis; Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Smiles

O=C(C1=C(C(C)C)SC(NC(C2=CC(NC(C3=CC=C(C#CC4=CSC=N4)C=C3)=O)=CN2C)=O)=N1)NCCCN(C)C

Molecular Formula

C30H33N7O3S2

Molecular Weight

603.76

References & Citations

[1]Msallam YA, et al. Design, Synthesis, and Anticancer Evaluation of Novel MGBs with Alkyne-Linked Thiazole Moieties. J Med Chem. 2025 Jul 24;68 (14) :15065-15084.