PXR ligand-Linker Conjugate 1
PXR ligand-Linker Conjugate 1 is a conjugate of PXR ligand and linker, which can be used to synthesize PROTAC MI1013 (HY-175266) [1].
Product Specifications
UNSPSC
12352005
Target
Pregnane X Receptor (PXR) ; Target Protein Ligand-Linker Conjugates
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=C(CCOCCOCCOCCN=[N+]=[N-])NC1=CC=C(C=C1)S(=O)(C2=C(N(N=N2)C3=CC(OC)=CC=C3OC)C)=O
Molecular Formula
C26H33N7O8S
Molecular Weight
603.65
References & Citations
[1]Kamaraj R, et al. Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation. J Med Chem. 2025 Jul 24;68 (14) :14271-14299.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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