PQ32
PQ32 is an antitumor agent that targets c-MYC Pu27 and KRAS G-quadruplexes. PQ32 inhibits tumor cell proliferation, arrests the cell cycle at the G2 phase, and induces apoptosis. PQ32 inhibits the expression of c-MYC and KRAS genes. PQ32 can inhibit tumor growth in mice and is used in the study of lymphoma, breast cancer, lung cancer, hepatocellular carcinoma, colorectal cancer, and other cancers[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Myc; Ras
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC(C=CC(CN1C=C2C(C3=CC4=C(C=C3)OCO4)=NN=C2C5=C1C=C6OCOC6=C5)=C7)=C7OC
Molecular Formula
C27H21N3O6
Molecular Weight
483.47
References & Citations
[1]Mohamed HI, et al. Development of Antitumor Drugs Targeting c-MYC Pu27 and KRAS G-Quadruplexes. J Med Chem. 2025 Jul 24;68 (14) :14223-14238.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
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