MI891
MI891 is a highly selective PXR antagonist (IC50 = 3.76 μM, Kd = 1.7 μM) and inverse agonist (IC50 = 6.1 μM) . MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin (HY-B0272) -induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases[1].
Product Specifications
CAS Number
[2530027-77-9]
UNSPSC
12352005
Target
Cytochrome P450; Pregnane X Receptor (PXR)
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O=C(N)C1=CC(CN2N=NC(C3=C(C4=CC=C(Cl)C=C4)N=C5C(F)=CC(F)=CN53)=C2)=CC=C1Cl
Molecular Formula
C23H14Cl2F2N6O
Molecular Weight
499.30
References & Citations
[1]Kamaraj R, et al. Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation. J Med Chem. 2025 Jul 24;68 (14) :14271-14299.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
More Discoveries
Explore Other Products
Browse additional items from our catalog
TP721574M 100 µg
AGRL2 Human Recombinant Protein, Synthetic Nanodisc
Sign In for Pricing
View Details 
MBS3903372-03 5x 0.01 mg
Rabbit anti-TPP1 Antibody, Affinity Purified
Sign In for Pricing
View Details MBS3903372-04 5x 0.1 mg
Rabbit anti-TPP1 Antibody, Affinity Purified
Sign In for Pricing
View Details