Aminochalcone 4AAF

Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures[1].

Product Specifications

CAS Number

[38239-51-9]

UNSPSC

12352005

Target

5-HT Receptor; GABA Receptor; Reactive Oxygen Species (ROS)

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Smiles

NC1=CC=C(C=C1)C(/C=C/C2=CC=CC=C2)=O

Molecular Formula

C15H13NO

Molecular Weight

223.27

References & Citations

[1]Bezerra AS, et al. Synthetic Aminochalcone Prevents Hyperglycemia-Induced Anxiety and Delays Pentylenetetrazole-Induced Epileptic Crisis in Adult Zebrafish. ACS Omega. 2025 Jul 14;10 (28) :30313-30326.