Mtb-IN-12
Mtb-IN-12 (Compound 5m) is a dual-target inhibitor that can target the CYP125 (KD: 40 nM; KI: 0.1 μM) and CYP142 (KD: 160 nM; KI: 0.05 μM) enzymes of Mycobacterium tuberculosis. Mtb-IN-12 exhibits good inhibitory activity against both drug-sensitive strains and multidrug-resistant tuberculosis strains, with low toxicity to macrophages. Mtb-IN-12 can be used in the research of anti-tuberculosis drugs[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; Cytochrome P450
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
COC1=CC=C(CNC2=CC=C(C=C2)CC3=CC=NC=C3)C=C1
Molecular Formula
C20H20N2O
Molecular Weight
304.39
References & Citations
[1]Kavanagh ME, et al. Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism. J Med Chem. 2025 Jul 24;68 (14) :14416-14441.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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