ZN-c5
ZN-c5 is a selective and orally active estrogen receptor degrader. ZN-c5 exhibits high potency in the cellular assay (MCF-7, IC50 = 0.3 nM) and binds with high affinity to ERα and ERβ (IC50 = 0.4 nM and 0.8 nM, respectively) . ZN-c5 inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 can be used for the study of breast cancer[1].
Product Specifications
CAS Number
2136606-87-4
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC1=CC(/C=C/C(O)=O)=CC(F)=C1[C@H]2N([C@@H](CC3=C2NC4=CC=CC=C43)C)C56CC(C6)C5
Molecular Formula
C26H24F2N2O2
Molecular Weight
434.48
References & Citations
[1]Hegde SG, et al. Discovery of ZN-c5, an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) with Improved Pharmacokinetics. J Med Chem. 2025 Jul 24;68 (14) :14740-14755.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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