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DHODH-IN-29

DHODH-IN-29 (Compound 2i) is a covalent inhibitor of Leishmania braziliensis Dihydroorotate Dehydrogenase (LbDHODH) with an IC50 value of 0.5 μM. DHODH-IN-29 is promising for research of antileishmaniasis[1].

Product Specifications

CAS Number

[212375-00-3]

UNSPSC

12352005

Target

Dihydroorotate Dehydrogenase; Parasite

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=CC=C2)=O

Molecular Formula

C13H10N2O3

Molecular Weight

242.23

References & Citations

[1]Froes TQ, et al. Barbituric Acid Derivatives as Covalent Inhibitors of Leishmania braziliensis Dihydroorotate Dehydrogenase. J Med Chem. 2025 Jul 14.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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