DHODH-IN-29
DHODH-IN-29 (Compound 2i) is a covalent inhibitor of Leishmania braziliensis Dihydroorotate Dehydrogenase (LbDHODH) with an IC50 value of 0.5 μM. DHODH-IN-29 is promising for research of antileishmaniasis[1].
Product Specifications
CAS Number
[212375-00-3]
UNSPSC
12352005
Target
Dihydroorotate Dehydrogenase; Parasite
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=CC=C2)=O
Molecular Formula
C13H10N2O3
Molecular Weight
242.23
References & Citations
[1]Froes TQ, et al. Barbituric Acid Derivatives as Covalent Inhibitors of Leishmania braziliensis Dihydroorotate Dehydrogenase. J Med Chem. 2025 Jul 14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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