PAD2/4-IN-1

PAD2/4-IN-1 (Compound 4f) is an orally active inhibitor of PAD2 and PAD4 with IC50 values of 23 nM and 10 nM, respectively. PAD2/4-IN-1 can inhibit protein citrullination in neutrophils and reduce hERG channel liabilities. PAD2/4-IN-1 can be used in the research of autoimmune diseases, neurological disorders, and cancers[1].

Product Specifications

UNSPSC

12352005

Target

Potassium Channel; Protein Arginine Deiminase

Related Pathways

Epigenetics; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Smiles

O=C(NC)[C@@H](N)C1CCN(C2=NC=CC3=C2C=CC=C3C4=NC(C5=NN(C)C=C5)=C(Cl)C=C4Cl)CC1

Molecular Formula

C26H27Cl2N7O

Molecular Weight

524.44

References & Citations

[1]Schnute M E, et al. Peptidylarginine Deiminase (PAD) Inhibitor Optimization through Displacement of a Trapped Water Molecule. ACS Medicinal Chemistry Letters, 2025.