Theophylline-platinum (IV) prodrug-1
Theophylline-platinum (IV) prodrug-1 is a PARP-1 inhibitor. Theophylline-platinum (IV) prodrug-1 enhances DNA damage, ROS production, mitochondrial dysfunction, apoptosis and S-phase arrest, along with reducing invasion and metastasis in cells. Theophylline-platinum (IV) prodrug-1 exhibits superior antitumor activity in the xenograft SKOV3-BRCA1-KD tumor model. Theophylline-platinum (IV) prodrug-1 can be used for the study of ovarian cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Cadherin; EGFR; ERK; NF-κB; PARP; Reactive Oxygen Species (ROS) ; TGF-β Receptor
Related Pathways
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
[NH3][Pt+4]([NH3])([O-]C(CN1C=NC(N(C(N2C)=O)C)=C1C2=O)=O)([O-]C(CCCCCCCCCCCCCCC)=O)([Cl-])[Cl-]
Molecular Formula
C25H46Cl2N6O6Pt
Molecular Weight
792.66
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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