GABAA receptor modulator-9

GABAA receptor modulator-9 is and positive allosteric modulator of a1β2y2 subtype GABAA that can cross the blood-brain barrier. GABAA receptor modulator-9 exhibits comparable activity on α1β2γ2 (EC50: 0.9 μM in oocytes, 0.2 μM in CHO cells) and on α1β2, α3β2γ2 and α1β3γ2 (EC50s of 1.3, 3.4 and 1.1 μM) . GABAA receptor modulator-9 significantly suppresses seizure progression and reduces delayed mortality. GABAA receptor modulator-9 can be used for the study of status epilepticus (SE) [1].

Product Specifications

UNSPSC

12352005

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C1N(C(c2ccccc2)=NC3=C1SC(C4=CC=CS4)=N3)C5=CC=CC=C5CC

Molecular Formula

C23H17N3OS2

Molecular Weight

415.53

References & Citations

[1]Liao W, et al. Novel 2- (2-Thienyl) -thiazolo[4,5-d]pyrimidin-7 (6H) -ones Binding β+/α- Subunit Interface as GABAAR Positive Allosteric Modulator for the Treatment of Status Epilepticus in Mouse. J Med Chem. 2025 Jul 10.