SOS1-IN-20
SOS1-IN-20 (Compound 12f) is an orally active SOS1 inhibitor with an IC50 of 5.11 nM against KRASG12C::SOS1. By disrupting the interaction between KRAS and SOS1, SOS1-IN-20 inhibits KRAS activation and downstream signal transduction. SOS1-IN-20 has an IC50 of 253 nM for p-ERK in PC-9 cells and 16.71 μM for hERG channel . SOS1-IN-20 can inhibit the proliferation of tumor cells and has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Potassium Channel; Ras; SOS1
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
C[C@H](C1=CC=CC(C(F)F)=C1F)NC(C2=CC(C3CC3)=CN=C2NC4CNC4)=O
Molecular Formula
C21H23F3N4O
Molecular Weight
404.43
References & Citations
[1]Li D, et al. Identification of Novel 2- (Azetidin-3-ylamino) nicotinamide Derivatives as Potent KRAS:: SOS1 Inhibitors. ACS Medicinal Chemistry Letters, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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