ADAR1-IN-1
ADAR1-IN-1 is a potent ADAR1 inhibitor. ADAR1-IN-1 significantly suppressed DU-145 cell proliferation (IC50 = 1.11 μM), clonogenicity, migration, and invasion, arrests cell cycle, and induces apoptosis. ADAR1-IN-1 safely and effectively inhibits tumor growth. ADAR1-IN-1 can be used for the study of prostate cancer (PCa) [1].
Product Specifications
CAS Number
2734853-87-1
UNSPSC
12352005
Target
Adenosine Deaminase; Apoptosis
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@@H]1[C@H](O)[C@@H](COS(=O)(C2=CC=C(C=C2)C(F)(F)F)=O)O[C@H]1N3C4=NC(F)=NC(N)=C4N=C3
Molecular Formula
C17H15F4N5O6S
Molecular Weight
493.39
References & Citations
[1]Zhu Y, et al. Design, Synthesis, and Activity Evaluation of Novel Nucleosides as ADAR1 Inhibitor for the Treatment of Prostate Cancer. J Med Chem. 2025 Jul 24;68 (14) :14495-14513.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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