ADAR1-IN-1

ADAR1-IN-1 is a potent ADAR1 inhibitor. ADAR1-IN-1 significantly suppressed DU-145 cell proliferation (IC50 = 1.11 μM), clonogenicity, migration, and invasion, arrests cell cycle, and induces apoptosis. ADAR1-IN-1 safely and effectively inhibits tumor growth. ADAR1-IN-1 can be used for the study of prostate cancer (PCa) [1].

Product Specifications

CAS Number

[2734853-87-1]

UNSPSC

12352005

Target

Adenosine Deaminase; Apoptosis

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O[C@@H]1[C@H](O)[C@@H](COS(=O)(C2=CC=C(C=C2)C(F)(F)F)=O)O[C@H]1N3C4=NC(F)=NC(N)=C4N=C3

Molecular Formula

C17H15F4N5O6S

Molecular Weight

493.39

References & Citations

[1]Zhu Y, et al. Design, Synthesis, and Activity Evaluation of Novel Nucleosides as ADAR1 Inhibitor for the Treatment of Prostate Cancer. J Med Chem. 2025 Jul 24;68 (14) :14495-14513.