PROTAC BRD4 Degrader-38
PROTAC BRD4 Degrader-38 is a BRD4 PROTAC degrader with DC50s of 86 and 106 nM for the short and long isoforms of BRD4, respectively. PROTAC BRD4 Degrader-38 significantly induces the degradation of BRD4 by covalently engaging C232 of E3 ligase TRIM28[1].Pink: BRD4 ligand (HY-78695) ; Blue: E3 ligase ligand (HY-203082) ; Black: linker (HY-40172)
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
ClC1=CC=C(C2=N[C@@H](CC(NCCCNC(C3=CC=C(/C=C/[N+]([O-])=O)C=C3)=O)=O)C4=NN=C(C)N4C5=C2C(C)=C(C)S5)C=C1
Molecular Formula
C31H30ClN7O4S
Molecular Weight
632.13
References & Citations
[1]Ouyang X, et al. Proteome-Wide Ligand and Target Discovery by Using β-Nitrostyrene Electrophiles: Supporting Targeted Protein Degradation. Angew Chem Int Ed Engl. 2025 Jun 4:e202504813.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Curated Selection
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