MEK4 IN-3
MEK4 IN-3 (Compound 39) is a selective MEK4 inhibitor with IC50s of 78 and 2920 nM for MEK4 and RSK4, respectively. MEK4 IN-3 reduces toxicity in cells. MEK4 IN-3 can be used for liver failure, particularly nonalcoholic fatty liver disease (NAFLD) research[1].
Product Specifications
UNSPSC
12352005
Target
MEK
Related Pathways
MAPK/ERK Pathway
Field of Research
Metabolic Disease
Smiles
N#CC1=CC(NC2=CC(N(C3CC3)C4)=C(C=N2)N(C)C4=O)=CC(F)=C1O
Molecular Formula
C18H16FN5O2
Molecular Weight
353.35
References & Citations
[1]Katzengruber L, et al. Discovery of the First Highly Selective 1,4-dihydropyrido[3,4-b]pyrazin-3 (2H) -one MKK4 Inhibitor. J Med Chem. 2025 Jul 24;68 (14) :14782-14805.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP2K4/MEK4
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