CHIKV nsP2 protease-IN-2
CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC50s of 0.5 μM and 0.9 μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC50 of 120 nM for CHIKV-nLuc) . CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research[1].
Product Specifications
UNSPSC
12352100
Target
Virus Protease
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N(CC1)CCC21CC(CN(CCCC3)S3(=O)=O)CCO2)C4(C5=CC=CC=C5)CCCC4
Molecular Formula
C26H38N2O4S
Molecular Weight
474.66
References & Citations
[1]Muthu Ramalingam B, et al. Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity. J Med Chem. 2025 Jul 24;68 (14) :14514-14536.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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