CHIKV nsP2 protease-IN-2

CHIKV nsP2 protease-IN-2 (Compound 2o) is a allosteric nonstructural protein 2 helicase (nsP2hel) inhibitor with IC50s of 0.5 μM and 0.9 μM for nsP2 ATPase and RNA unwindase, respectively. CHIKV nsP2 protease-IN-2 has broad-spectrum antialphaviral activity against chikungunya virus (CHIKV), Mayaro virus (MAYV), and Venezuelan equine encephalitis virus (VEEV) (EC50 of 120 nM for CHIKV-nLuc) . CHIKV nsP2 protease-IN-2 can be used for alphaviruses infections research[1].

Product Specifications

UNSPSC

12352100

Target

Virus Protease

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C(N(CC1)CCC21CC(CN(CCCC3)S3(=O)=O)CCO2)C4(C5=CC=CC=C5)CCCC4

Molecular Formula

C26H38N2O4S

Molecular Weight

474.66

References & Citations

[1]Muthu Ramalingam B, et al. Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity. J Med Chem. 2025 Jul 24;68 (14) :14514-14536.