GL64

GL64 is a selective agonist of ADGRD1 (EC50 = 3.98 μM) . GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases[1].

Product Specifications

CAS Number

[488801-10-1]

UNSPSC

12352005

Target

Endogenous Metabolite; Nuclear Factor of activated T Cells (NFAT)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Endocrinology

Purity

98.80

Smiles

O=C1C2=CC=CC=C2NC(N1C3=CC=C(C=C3)Cl)C4=CC(OCC5=C(C=C(C=C5)Cl)Cl)=CC=C4

Molecular Formula

C27H19Cl3N2O2

Molecular Weight

509.81

References & Citations

[1]He L, et al. Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis. Sci Adv. 2025 Jul 11;11 (28) :eads3829.