ZG-2492
ZG-2492 is an orally active LDHA inhibitor with an IC50 of 156 nM. ZG-2492 can reduce lactate production and induce cell cycle arrest and apoptosis in pancreatic cancer cells . ZG-2492 has antitumor activity and can be used in the research of tumors such as pancreatic cancer[1].
Product Specifications
CAS Number
3084810-37-4
UNSPSC
12352005
Target
Apoptosis; Lactate Dehydrogenase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
ClC1=CC=C(C#N)C=C1NS(C2=CC(N3CCN(CC3)CCC(O)=O)=CC=C2)(=O)=O
Molecular Formula
C20H21ClN4O4S
Molecular Weight
448.92
References & Citations
[1]Gong Q, et al. Machine-Learning-Driven Discovery of N-Phenylbenzenesulfonamides as a Novel Chemotype for Lactate Dehydrogenase A Inhibition with Anti-Pancreatic Cancer Activity. J Med Chem. 2025 Jul 24;68 (14) :14384-14404.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA
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