RNA MTase-IN-1
RNA MTase-IN-1 (Compound 47) is a RNA methyltransferase (RNA MTase) inhibitor with an IC50 of 68 μM for 16S rRNA (m1A1408) methyltransferase (NpmA) . RNA MTase-IN-1 has a significant inhibitory activity against pathogen-associated aminoglycoside-resistance. RNA MTase-IN-1 can be used for resistant bacterial infections research[1].
Product Specifications
UNSPSC
12352005
Target
Bacterial; RNA MTase
Related Pathways
Anti-infection; Epigenetics
Field of Research
Infection
Smiles
CC1=CC=C(C=C1)NC(/C(NC(C2=CC=C(C=C2Cl)Cl)=O)=C/C3=CC([N+]([O-])=O)=CC=C3)=O
Molecular Formula
C23H17Cl2N3O4
Molecular Weight
470.30
References & Citations
[1]Dey D, et al. Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase. ACS Infect Dis. 2025 Jul 11.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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