RNA MTase-IN-1

RNA MTase-IN-1 (Compound 47) is a RNA methyltransferase (RNA MTase) inhibitor with an IC50 of 68 μM for 16S rRNA (m1A1408) methyltransferase (NpmA) . RNA MTase-IN-1 has a significant inhibitory activity against pathogen-associated aminoglycoside-resistance. RNA MTase-IN-1 can be used for resistant bacterial infections research[1].

Product Specifications

UNSPSC

12352005

Target

Bacterial; RNA MTase

Related Pathways

Anti-infection; Epigenetics

Field of Research

Infection

Smiles

CC1=CC=C(C=C1)NC(/C(NC(C2=CC=C(C=C2Cl)Cl)=O)=C/C3=CC([N+]([O-])=O)=CC=C3)=O

Molecular Formula

C23H17Cl2N3O4

Molecular Weight

470.30

References & Citations

[1]Dey D, et al. Discovery of First-in-Class Inhibitors Targeting a Pathogen-Associated Aminoglycoside-Resistance 16S rRNA Methyltransferase. ACS Infect Dis. 2025 Jul 11.