STAT3/NF-κB-IN-1

STAT3/NF-κB-IN-1 is a potentSTAT3 and NF-κB inhibitor with IC50s of 5.86 (STAT3) and 4.22 μM (NF-κB) in 4T1 cells. STAT3/NF-κB-IN-1 is able to induce apoptosis via its upregulation on key apoptotic regulators; caspases-3/9, Bax and downregulation of Bcl-2. STAT3/NF-κB-IN-1 exerts considerable anticancer activity against breast cancer cell lines and reduces tumor volume in vivo. STAT3/NF-κB-IN-1 can be used for the study of breast cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Bcl-2 Family; Caspase; NF-κB; STAT

Related Pathways

Apoptosis; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CCN1C(SCC(N/N=C\C2=CN(N=C2C3=CC=CC=C3)C4=CC=CC=C4)=O)=NC5=C1C(N(C(N5C)=O)C)=O

Molecular Formula

C27H26N8O3S

Molecular Weight

542.61

References & Citations

[1]Afifi OS, et al. Revisiting multi-pathway modulation with theophylline derivatives: Targeting STAT3, NF-κB, and apoptotic signaling in breast cancer. Bioorg Chem. 2025 Jun 30;163:108708.