STAT3/NF-κB-IN-1
STAT3/NF-κB-IN-1 is a potentSTAT3 and NF-κB inhibitor with IC50s of 5.86 (STAT3) and 4.22 μM (NF-κB) in 4T1 cells. STAT3/NF-κB-IN-1 is able to induce apoptosis via its upregulation on key apoptotic regulators; caspases-3/9, Bax and downregulation of Bcl-2. STAT3/NF-κB-IN-1 exerts considerable anticancer activity against breast cancer cell lines and reduces tumor volume in vivo. STAT3/NF-κB-IN-1 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; NF-κB; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CCN1C(SCC(N/N=C\C2=CN(N=C2C3=CC=CC=C3)C4=CC=CC=C4)=O)=NC5=C1C(N(C(N5C)=O)C)=O
Molecular Formula
C27H26N8O3S
Molecular Weight
542.61
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; Caspase 9; NF-κB; STAT3
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Anti-JHDM3A/JMJD2A/KDM4A Antibody Picoband® Fluoro594 Conjugated
HDAC2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
CD62E (LECAM, E-Selectin, ELAM1, Endothelial Leukocyte Adhesion Molecule) (Biotin)