DPP8/9-IN-2

DPP8/9-IN-2 (Compound 21) is a DPP8/9 inhibitor with IC50 values of 0.22 nM and 3 nM, respectively, and Ki values of 2.9 nM and 6 nM, respectively . DPP8/9-IN-2 has certain cardiotoxicity, with IC50 values of 0.7 μM, 29.0 μM and 27.7 μM for hERG potassium channel, Nav1.5 sodium channel and Cav1.2 calcium channel, respectively. DPP8/9-IN-2 can be used in the research of diseases such as tumors[1].

Product Specifications

UNSPSC

12352005

Target

Calcium Channel; Dipeptidyl Peptidase; Potassium Channel; Sodium Channel

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(N1CC2=C(C=C(F)C=C2)C1)[C@@H](N)CC(N3CCC(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O

Molecular Formula

C30H30F3N3O2

Molecular Weight

521.57

References & Citations

[1]Nozal V, et al. Highly potent dipeptidyl peptidase 8/9 (DPP8/9) inhibitors designed via relative binding free energy calculations. Eur J Med Chem. 2025 Nov 5;297:117913.