PROTAC BRD4 Degrader-37

PROTAC BRD4 Degrader-37 (Compound TrimTAC-2) is a PROTAC BRD4 degrader. PROTAC BRD4 Degrader-37 has a DC50 of 36.4 nM and a Dmax of 73% in PANC-1 cells. PROTAC BRD4 Degrader-37 exhibits cytotoxicity against PANC-1 cells (GI50: 0.282 μM) . PROTAC BRD4 Degrader-37 can be used in the research of tumors. (Pink: PROTAC BRD4 ligand-4 (HY-175242) ; Blue + Black: E3 ligase ligand + linker (HY-175241) ) [1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CSC1=CC=CC=C1C2=CC(S(C)(=O)=O)=C(C=C2)C(N(CC3CCCCC3)CCCCCCCNC(C4=CC5=C(C(C)=CC(C6=CN(C(C(C)=C6)=O)C)=C5)O4)=O)=O

Molecular Formula

C46H55N3O6S2

Molecular Weight

810.08

References & Citations

[1]Zhang L, et al. TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms. J Chem Inf Model. 2025 Jul 28;65 (14) :7584-7604.