PROTAC BRD4 Degrader-36
PROTAC BRD4 Degrader-36 is a BRD4 PROTAC degrader. PROTAC BRD4 Degrader-36 has a DC50 of 0.649 nM and a Dmax of 71% in PANC-1 cells. PROTAC BRD4 Degrader-36 is cytotoxic to PANC-1 cells (GI50: 0.103 μM) . PROTAC BRD4 Degrader-36 can be used in the study of cancer. (Pink: PROTAC BRD4 ligand-1 (HY-129939) ; Blue + Black: E3 ligase ligand + linker (HY-175241) ) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(C1=C(C=C2C3=CN(C(C4=C3C(CN(C2=C1)C5=NC=C(C=C5F)F)=CN4)=O)C)CS(C)(=O)=O)NCCCCCCCN(CC6CCCCC6)C(C7=C(S(=O)(C)=O)C=C(C=C7)C8=CC=CC=C8SC)=O
Molecular Formula
C52H58F2N6O7S3
Molecular Weight
1013.24
References & Citations
[1]Zhang L, et al. TRIM21-Driven Degradation of BRD4: Development of Heterobifunctional Degraders and Investigation of Recruitment and Selectivity Mechanisms. J Chem Inf Model. 2025 Jul 28;65 (14) :7584-7604.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Curated Selection
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