GlcNAc-MurNAc
GlcNAc-MurNAc, a disaccharide, is a TLR4 agonist with a Kd of 383 μM for murine TLR4. GlcNAc-MurNAc directly binds to TLR4 and activates its downstream NF-κB and IRF pathways. GlcNAc-MurNAc improves Dextran sulfate sodium salt (DSS) -induced colitis in mice through a TLR4-dependent mechanism. GlcNAc-MurNAc can be used for the study of inflammatory bowel disease[1].
Product Specifications
CAS Number
41137-10-4
UNSPSC
12352005
Target
Caspase; Interleukin Related; NF-κB; TNF Receptor; Toll-like Receptor (TLR)
Related Pathways
Apoptosis; Immunology/Inflammation; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
OC([C@@H](C)O[C@H]([C@H](C(O[C@@H]1CO)O)NC(C)=O)[C@@H]1O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)NC(C)=O)=O
Molecular Formula
C19H32N2O13
Molecular Weight
496.46
References & Citations
[1]Li C, et al. Gut microbiota-derived GlcNAc-MurNAc is a TLR4 agonist that protects the host gut. Nat Commun. 2025 Jul 1;16 (1) :5577.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-1; IL-12; IL-6; NF-κB; TLR4
Available Sizes
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