4-TCPA
4-TCPA is a potent VEGFR2 inhibitor. 4-TCPA induces apoptosis and cell cycle arrest, likely through inhibition of VEGFR2 and EGFR signaling with additional effects on the mTOR pathway. 4-TCPA can inhibit the vitality and proliferation of various cancer cell lines. 4-TCPA can be used for the study of cancers such as lung cancer, breast cancer and leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; EGFR; mTOR; VEGFR
Related Pathways
Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(Cl)C=C1)CN2N=NC(CNC3=C4C=C(OCCOC)C(OCCOC)=CC4=NC=N3)=C2
Molecular Formula
C25H28ClN7O5
Molecular Weight
541.99
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-175220/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; VEGFR2/KDR/Flk-1
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