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4-TCPA

4-TCPA is a potent VEGFR2 inhibitor. 4-TCPA induces apoptosis and cell cycle arrest, likely through inhibition of VEGFR2 and EGFR signaling with additional effects on the mTOR pathway. 4-TCPA can inhibit the vitality and proliferation of various cancer cell lines. 4-TCPA can be used for the study of cancers such as lung cancer, breast cancer and leukemia[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR; mTOR; VEGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C(NC1=CC=C(Cl)C=C1)CN2N=NC(CNC3=C4C=C(OCCOC)C(OCCOC)=CC4=NC=N3)=C2

Molecular Formula

C25H28ClN7O5

Molecular Weight

541.99

References & Citations

[1]Dehghan-Nayeri MJ, et al. Synthesis, characterization, anti-proliferative, and apoptotic activity of a novel quinazoline-containing 1,2,3-triazole toward three human cancer cells. Sci Rep. 2025 Jul 1;15 (1) :20852.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MTOR; VEGFR2/KDR/Flk-1

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