CA-II/Dkk1-IN-1

CA-II/Dkk1-IN-1 (Compound 5d) is a dual-functional inhibitor of CA-II and Dkk1 with a IC50 of 6.90 nM for CA-II. CA-II/Dkk1-IN-1 has significantly antioxidant activity and superior DNA binding capacity. CA-II/Dkk1-IN-1 can be used for cancers research, such as esophageal, renal, and lung cancer[1].

Product Specifications

UNSPSC

12352005

Target

Carbonic Anhydrase

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=S(C1=CC=C(NC(S2)=NC(C2=C(C3=CC4=C(C=C3)N(CC)C5=C4C=CC=C5)N6)=NC6=S)C=C1)(N)=O

Molecular Formula

C25H20N6O2S3

Molecular Weight

532.66

References & Citations

[1]Bilal MS, et al. Synthesis, in vitro evaluation and computational modelling of benzene sulfonamide derivatives as Dickkopf 1 inhibitors for anticancer drug development. Sci Rep. 2025 Jul 1;15 (1) :21049.