Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6

Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6 is a drug-linker conjugate for ADC. Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6 consists of a topoisomerase 1 inhibitor (Topi MF-6) (HY-175203) and a cleavable linker (Maleimide-Ph (3,5-F) -PEG4-Val-Ala) (HY-175218) . Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6 can be used for synthesis of ADCs[1].

Product Specifications

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC; Topoisomerase

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

FC(C=C1N2C(C=CC2=O)=O)=C(C(F)=C1)OCCOCCOCCOCC(N[C@@H](C(C)C)C(N[C@H](C(NC3=CC=C4N=C5C6=CC7=C(C(N6CC5=C8C4=C3CCC8(F)F)=O)COC([C@@]7(CC)O)=O)=O)C)=O)=O

Molecular Formula

C49H50F4N6O13

Molecular Weight

1006.95

References & Citations

[1]Wang R, et al. Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor. Cell Rep Med. 2025 Jul 15;6 (7) :102213.