Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6
Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6 is a drug-linker conjugate for ADC. Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6 consists of a topoisomerase 1 inhibitor (Topi MF-6) and a cleavable linker (Maleimide-Ph (3,5-F) -PEG4-Val-Ala) (HY-175218). Maleimide-Ph (3,5-F) -PEG4-Val-Ala-MF-6 can be used for synthesis of ADCs[1].
Product Specifications
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC; Topoisomerase
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC(C=C1N2C(C=CC2=O)=O)=C(C(F)=C1)OCCOCCOCCOCC(N[C@@H](C(C)C)C(N[C@H](C(NC3=CC=C4N=C5C6=CC7=C(C(N6CC5=C8C4=C3CCC8(F)F)=O)COC([C@@]7(CC)O)=O)=O)C)=O)=O
Molecular Formula
C49H50F4N6O13
Molecular Weight
1006.95
References & Citations
[1]Wang R, et al. Overcoming multidrug resistance in gastrointestinal cancers with a CDH17-targeted ADC conjugated to a DNA topoisomerase inhibitor. Cell Rep Med. 2025 Jul 15;6 (7) :102213.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Frequently Asked Questions
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