STING-IN-16

STING-IN-16 is a STING inhibitor with IC50 values of 44 nM (human) and 32 nM (mice) for cellular STING inhibition. STING-IN-16 effectively inhibits the activation of the STING axis in both human and murine cells. STING-IN-16 can restore renal mitochondrial function, suppress reactive oxygen species (ROS) production, and reduce cell apoptosis. STING-IN-16 shows robust anti-inflammatory efiicacy in vivo. STING-IN-16 can be used for the study of autoimmune and autoinflammatory diseases[1].

Product Specifications

CAS Number

[2982807-58-7]

UNSPSC

12352005

Target

Apoptosis; IFNAR; Interleukin Related; Reactive Oxygen Species (ROS) ; STING

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

O=C(N1CCC2=C(C1)C=CC(C3=CC=C(C=C3)OC)=C2)NC4=CNC5=C4C=C(C=C5)Cl

Molecular Formula

C25H22ClN3O2

Molecular Weight

431.91

References & Citations

[1]Zhou X, et al. Discovery of 3,4-dihydroisoquinoline-2 (1H) -carboxamide STING inhibitors as anti-inflammatory agents. Eur J Med Chem. 2025 Jul 1;297:117922.