Nrf2-IN-4

Nrf2-IN-4 is a Nrf2 inhibitor. Nrf2-IN-4 induces ferroptosis via NRF2 inhibition. Nrf2-IN-4 disrupts cellular iron homeostasis, facilitates ferritin degradation, and ultimately triggers ferroptosis. Nrf2-IN-4 induces lysosome activation by promoting iron-dependent ROS production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor efficacy. Nrf2-IN-4 can be used for the study of breast cancer[1].

Product Specifications

CAS Number

[2417486-06-5]

UNSPSC

12352005

Target

Atg8/LC3; Ferroptosis; Keap1-Nrf2; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

ClC1=C(Cl)C=C(C2=CSC(N/N=C(C3=CC=CC=N3)/C4=NC=CC=C4)=N2)C=C1

Molecular Formula

C20H13Cl2N5S

Molecular Weight

426.32

References & Citations

[1]Meng X, et al. Discovery of novel thiazolylhydrazone derivatives as potent anti-cancer agents inducing ferroptosis via direct NRF2 inhibition. Eur J Med Chem. 2025 Jun 28;297:117912.