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TGF-β2-IN-1

TGF-β2-IN-1 is a selective TGF-β2 inhibitor. TGF-β2-IN-1 exhibits potent antiproliferative effects on HCT-116, Caco-2 and HT-29 with IC50 values of 6.84, 10.21, and 9.47 μM, respectively. TGF-β2-IN-1 inhibits TGF-β2 signaling in a dose-dependent manner by suppressing both receptor and cytokine expression.TGF-β2-IN-1 can be used for the study of colorectal cancer[1].

Product Specifications

UNSPSC

12352005

Target

TGF-beta/Smad

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

COC1=CC=CC(/C=N/NC(C2=CC=CC=C2OCC3=CN(N=N3)CC4=CC(Cl)=CC=C4)=O)=C1

Molecular Formula

C25H22ClN5O3

Molecular Weight

475.93

References & Citations

[1]Ay EN, et al. Synthesis, characterization, In vitro and In silico investigations of novel 1,2,3-triazole substituted salicylic acid phenolic hydrazones hybrids targeting TGF-β2 expression in colorectal carcinoma. Eur J Med Chem. 2025 Oct 15;296:117915.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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