SHP2 protein degrader-3
SHP2 protein degrader-3 is a SHP2 AUTAC degrader. SHP2 protein degrader-3 shows dose-dependent SHP2 degradation ability (DC50 = 3.22 μM) and anti-tumor activity (IC50 = 5.59 μM) in HeLa cells. SHP2 protein degrader-3 induces degradation through the LC3-mediated autophagy pathway, which can be inhibited by lysosome inhibitors. SHP2 protein degrader-3 induces apoptosis in various cancer cells (HeLa cells, HepG2 cells, LoVo cells, Huh-7 cells) (SHP2 Ligand : (HY-100388) ; LC3 Ligand: (HY-10542) ; Linker : (HY-128834) ) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Atg8/LC3; AUTACs; Autophagy; SHP2
Related Pathways
Apoptosis; Autophagy; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CC1(CCN(CC1)C2=CN=C(C(N)=N2)C3=CC=CC(Cl)=C3Cl)NCC4=CN(CCOCCOCCOCCOCCNC(COC5=C(C=C(C=C5Br)/C=C6C(NC7=C\6C=C(C=C7)I)=O)Br)=O)N=N4
Molecular Formula
C46H51Br2Cl2IN10O7
Molecular Weight
1213.58
References & Citations
[1]Song H, et al. Discovery of SA-8 as a potent SHP2-AUTAC degrader in cancer therapy. Eur J Med Chem. 2025 Jun 27;297:117918.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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