DEL-S1
DEL-S1 is a SLIT2 binder. DEL-S1 significantly impairs SLIT2/ROBO1 complex formation by inducing conformational rearrangements, further inhibits its function with an IC50 of 68.8 μM. DEL-S1 can be used for neural development, immune regulation and cancers like glioblastoma research[1].
Product Specifications
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Purity
98.0100
Smiles
N#CC1=CC=CC=C1N(CC2)CCN2C3=NC(N(CC)C4CCCCC4)=NC(N[C@@H](C(NC)=O)CC(N)=O)=N3
Molecular Formula
C27H38N10O2
Molecular Weight
534.66
References & Citations
[1]Yuan S, et al. Discovery of a First-in-Class SLIT2 Binder Disrupting the SLIT2/ROBO1 Axis via DNA-Encoded Library (DEL) Screening. bioRxiv [Preprint]. 2025 Jun 22:2025.06.22.660907.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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