MP1202
MP1202 is a dual-functional agonist of MOR and KOR with EC50s of 0.32 and 0.13 μM for mMOR-1 and mKOR-1, respectively. MP1202 has functional selectivity with reduction of β-arrestin1/2 recruitment but significant activation of G-protein and Gα-subtype at hMOR and hKOR. MP1202 has potent antinociceptive effects without typical opioid side effects, but it shows conditioned place preference and aversion behaviors in subtype-selective opioid KO mice model, promising for analgesia research[1].
Product Specifications
CAS Number
2578974-82-8
UNSPSC
12352005
Target
Arrestin; Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1=CC(I)=CC=C1)N[C@H]2[C@@](O3)([H])[C@]4(CCN5CC6CC6)C(C3=C7O)=C(C=C7)C[C@]5([H])[C@]4([H])CC2
Molecular Formula
C27H29IN2O3
Molecular Weight
556.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Arrestin-2/β-Arrestin 1; κ Opioid Receptor/KOR; μ Opioid Receptor/MOR
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