MP1202

MP1202 is a dual-functional agonist of MOR and KOR with EC50s of 0.32 and 0.13 μM for mMOR-1 and mKOR-1, respectively. MP1202 has functional selectivity with reduction of β-arrestin1/2 recruitment but significant activation of G-protein and Gα-subtype at hMOR and hKOR. MP1202 has potent antinociceptive effects without typical opioid side effects, but it shows conditioned place preference and aversion behaviors in subtype-selective opioid KO mice model, promising for analgesia research[1].

Product Specifications

CAS Number

[2578974-82-8]

UNSPSC

12352005

Target

Arrestin; Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1=CC(I)=CC=C1)N[C@H]2[C@@](O3)([H])[C@]4(CCN5CC6CC6)C(C3=C7O)=C(C=C7)C[C@]5([H])[C@]4([H])CC2

Molecular Formula

C27H29IN2O3

Molecular Weight

556.44

References & Citations

[1]Varga BR, et al. Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic. ACS Chem Neurosci. 2025 Jul 16;16 (14) :2714-2737.